Beilstein J. Nanotechnol.2014,5, 1312–1319, doi:10.3762/bjnano.5.144
chemotherapeutic agent due to its poor water-solubility and chemical instability and, as a consequence, no effective administration means have been designed. In this work, camptothecin has been successfully loaded into ironoxidesuperparamagneticnanoparticles with an average size of 14 nm. It was found that
; cancer therapy; ironoxidesuperparamagneticnanoparticles; polyethylene glycol; Introduction
Camptothecin (CPT) is a quinoline based alkaloid, which exhibits a potent cytotoxic activity against a broad spectrum of tumours [1][2][3]. While most antineoplastic agents inhibit cancer cell proliferation by
, since an increase of the time during which the cell cultures are incubated with the formulations leads to an increased apoptosis (data not shown).
In summary, two new CPT formulations based on ironoxidesuperparamagneticnanoparticles have been described and characterized by FTIR. Both formulations
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Figure 1:
Molecular structure of (S)-(+)-camptothecin (1) and its inactive form (2) through lactone ring hydr...